Analysis identifies genetic variants linked to type 2 diabetes and eating behaviors, suggesting genetic predispositions.
Key Points
This research aims to investigate the association between cholinergic receptor gene variants and type 2 diabetes mellitus as well as disturbed eating behaviors.
Examined DNA samples from 992 individuals with T2DM and 1,023 healthy controls.
Conducted DEBQ-based assessments of eating behavior.
Investigated specific polymorphic loci using real-time PCR.
Identified associations between T2DM and CHRNA5 rs16969968 (OR 1.72) and CHRNA3 rs1051730 (OR 1.812).
Found psychological eating behaviors linked to several gene variants, including CHRM1 rs2067477 (P = 0.014).
Established associations of haplotypes with T2DM, specifically with the AA and AAT haplotypes.