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March 4, 2026Diagnostic PathologyOpen Access

Subclassification of atypical endometrial cells (Not Otherwise Specified vs favor neoplasia) on Pap tests: age-dependent risk of endometrial neoplasia

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Authors

XZXin ZhouYZYi ZhouSHSuming Huang

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Overview

Analysis evaluates histological outcomes of atypical endometrial cells in women, highlighting age-related cancer risks.

Key Points

  • The study aims to assess the histological outcomes in women with atypical endometrial cells (AEMc) and the role of HPV status and age in cancer risk.
  • Retrospective analysis of 163 women with atypical endometrial cells diagnosed from January 2019 to December 2023
  • Conducted liquid-based cytology (LBC) and high-risk HPV testing for 14 genotypes
  • Performed histological evaluation within six months of cytological assessment
  • 86.5% of AEMc cases were classified as AEMc-not otherwise specified (NOS)
  • Significantly higher pathological severity in AEMc-favor neoplasia (FN) compared to AEMc-NOS
  • Older women (aged > 65) had a higher prevalence of high-grade endometrial lesions, indicating greater risk

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd4fd48f933b5eed9794https://doi.org/10.1186/s13000-026-01774-y
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