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Synapse
March 4, 20260 citations

Risk factors for major gastrointestinal bleeding in septic patients: a multicenter retrospective study.

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YZYi ZhangHZHeng ZhangYFYuanyuan Feng

Key Points

  • This research aims to identify the risk factors for major gastrointestinal bleeding (MGB) in septic patients.
  • Multicenter retrospective design
  • Analysis of patient data from multiple hospitals
  • Examination of correlations between MGB and various clinical factors
  • MGB occurred in 2.0% of septic patients but was linked to significantly higher mortality rates.
  • Older age and renal dysfunction were significant risk factors.
  • Elevated BUN levels and gastrointestinal sources were key drivers of risk.
  • Urinary tract infection was associated with lower risk of MGB.

Abstract

Although MGB occurred in only 2.0% of septic patients, it was associated with substantially higher mortality. Older age, renal dysfunction, elevated BUN and gastrointestinal sources were key drivers of risk, while urinary tract infection was associated with a lower risk. These findings underscore the importance of early risk stratification and targeted preventive strategies in high-risk patients to mitigate bleeding events and improve survival.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd9dd48f933b5eeda27ehttps://doi.org/10.1080/00365521.2026.2636063
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gastric Microbiome Alterations in Sepsis‐Related Gastrointestinal Bleeding: Two Case Reports and Literature Review2026
  2. 2Revisiting gastrointestinal bleeding risk in critically injured trauma patients: implications from recent evidence2026
  3. 3B25-20 Predictors of Short-term Mortality in ICU Patients With Gastrointestinal Bleeding: A Systematic Review and Meta-analysis2026
  4. 4Incidence of Acute Upper Gastrointestinal Bleeding and Related Risk Factors among Elderly Patients Undergoing Surgery for Major Limb Fractures: An Analytical Cohort Study2023 · 4 citations
  5. 5Independent predictors of ICU admission, mortality, and intervention requirements in acute upper gastrointestinal bleeding2025