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This research investigates how B-cell receptor (BCR) diversity influences responses to glucocorticoid therapy in pediatric idiopathic nephrotic syndrome (INS).

March 5, 2026Open Access

Unraveling BCR Repertoire Diversity and its Impact on Glucocorticoid Therapy in Pediatric Idiopathic Nephrotic Syndrome

Key Points

This research investigates how B-cell receptor (BCR) diversity influences responses to glucocorticoid therapy in pediatric idiopathic nephrotic syndrome (INS).
Analyzed immune profiles in pediatric patients with idiopathic nephrotic syndrome.
Compared responses to glucocorticoids in non-refractory vs. steroid-resistant and steroid-dependent groups.
Evaluated the correlation between BCR repertoire diversity and treatment outcomes.
Non-refractory nephrotic syndrome patients showed clonal B-cell expansion due to antigen-driven responses.
Steroid-resistant and steroid-dependent patients exhibited persistent IgE-mediated responses, leading to glucocorticoid resistance.
Findings suggest different immunological responses that can guide personalized treatment strategies.

Abstract

B-cell-mediated humoral immunity plays a pivotal role in INS pathogenesis, with distinct immune profiles associated with clinical outcomes. Non- refractory nephrotic syndrome (NRNS) patients exhibit clonal expansion with antigen-driven immune responses, whereas SRNS and RNS patients demonstrate persistent IgE-mediated responses that are resistant to GC but sensitive to second-line immunosuppressants. These findings offer new insights into the mechanisms of steroid resistance and provide a basis for early diagnosis and personalized treatment strategies in INS.

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Discussion

Authors

Yeping Luo

Chan Zou

Xinjie Yu

Journals

Journal of Clinical Immunology

Actions

Institutions

Sun Yat-sen University

Central South University

University of South China

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Unraveling BCR Repertoire Diversity and its Impact on Glucocorticoid Therapy in Pediatric Idiopathic Nephrotic Syndrome

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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