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March 5, 20260 citations

Synergistic action of human milk oligosaccharides and lactoferrin enhances neurodevelopment in piglets: evidence from MRS based metabolic profiling.

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MAM. AminCharles Sturt UniversityTAT. AminCharles Sturt UniversityAAAdikari Arachchige Dilki Indrachapa AdikariCharles Sturt University

Key Points

  • To investigate the combined effects of human milk oligosaccharides and lactoferrin on neurodevelopment in piglets.
  • Utilized metabolic profiling via MRS (Magnetic Resonance Spectroscopy)
  • Administered combined supplements of cHMOs and lactoferrin to piglets
  • Measured outcomes related to lipid mobilization, energy metabolism, and antioxidant capacity
  • cHMOs and lactoferrin supplementation enhanced lipid mobilization and energy metabolism
  • Combined supplementation showed improved antioxidant capacity
  • cHMOs alone promoted better neuronal integrity and synaptic activity in piglets

Abstract

The combined cHMOs and Lf supplementation may synergistically support neurodevelopment by enhancing lipid mobilization, energy metabolism, and antioxidant capacity, while cHMOs alone promotes brain development by improving neuronal integrity and synaptic activity in piglets - a translational model for human infants. To our knowledge, these findings have not been previously reported.

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Cite This Study

Amin et al. (2026) studied this question.

synapsesocial.com/papers/69a91d6dd6127c7a504c01d7https://doi.org/10.1080/1028415x.2026.2637610
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