The Impact of Micellar Coenzyme Q10 and Liposomal Coenzyme Q10 on TNF-α and IL-1β in Cisplatin-Induced Nephrotoxicity in Rats

Abstract Cisplatin is a widely used chemotherapeutic agent, but its clinical application is often limited due to its nephrotoxic effects, largely mediated through proinflammatory cytokines. This study investigates the comparative effectiveness of micellar and liposomal formulations of Coenzyme Q10 (CoQ10) in modulating serum levels of tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) in a rat model of cisplatin-induced nephrotoxicity. Ninety Wistar rats were divided into control group and five experimental groups receiving various treatments, including cisplatin alone, micellar CoQ10, liposomal CoQ10, and combinations thereof. Serum concentrations of TNF-α and IL-1β were measured at defined intervals using ELISA. The results demonstrated that both formulations of CoQ10 significantly reduced cytokine levels compared to cisplatin-only treated rats, with the liposomal form yielding superior anti-inflammatory effects. These findings suggest that liposomal CoQ10 may offer a more effective strategy for mitigating inflammation and nephrotoxicity induced by cisplatin.