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March 5, 2026Health Technology Assessment0 citationsOpen Access

Effectiveness of polyhexanide, chlorhexidine with neomycin and mupirocin for nasal methicillin-resistant Staphylococcus aureus (MRSA) decolonisation: non-inferiority RCT (TIDE)

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LCLiz CookSJSophie JamesJLJoanne Laycock

Key Points

  • The research aims to evaluate the effectiveness of various antiseptic agents in decolonising MRSA.
  • Conducted a non-inferiority randomized controlled trial (RCT)
  • Evaluated effectiveness of polyhexanide, chlorhexidine with neomycin, and mupirocin
  • Focused on nasal decolonisation of methicillin-resistant Staphylococcus aureus
  • Demonstrated no significant differences in decolonisation rates among the treatments
  • Indicated that polyhexanide and chlorhexidine with neomycin are as effective as mupirocin

Abstract

This synopsis presents independent research funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme as award number NIHR132718.

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Cite This Study

Cook et al. (2025) studied this question.

synapsesocial.com/papers/69a91d8dd6127c7a504c0786https://doi.org/10.3310/gjmr0715
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Using publicly available UK datasets to identify recruitment sites to maximise inclusion of under-served groups: three case studies2024 · 5 citations
  2. 2Hospitalizations and Deaths Caused by Methicillin-Resistant Staphylococcus aureus , United States, 1999–20052007 · 866 citations
  3. 3“I am there just to get on with it”: a qualitative study on the labour of the patient and public involvement workforce2024 · 8 citations
  4. 4Treatment of familial staphylococcal infection—comparison of mupirocin nasal ointment and chiorhexidine/neomycin (Naseptin) cream in eradication of nasal carriage1993 · 33 citations
  5. 5Activity of the antiseptic polyhexanide against meticillin-susceptible and meticillin-resistant Staphylococcus aureus2013 · 13 citations