MCC-135 Exerts Antiepileptic and Neuroprotective Effects by Downregulating NCX1 Expression to Decrease Intracellular Calcium Overload in the Hippocampus.

Puntos clave

• The study aims to investigate the effects of MCC-135 on calcium overload and its implications for epilepsy treatment.
• Examined the expression of NCX1 in the hippocampus following MCC-135 treatment.
• Assessed calcium levels and glutamate concentrations in the hippocampal region.
• Proposed a mechanism for MCC-135's action in reducing epilepsy symptoms.
• MCC-135 significantly downregulated NCX1 expression.
• Resulted in decreased intracellular calcium levels.
• Led to reduced glutamate levels in the hippocampus.