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March 5, 2026Ecotoxicology and Environmental SafetyOpen Access

Exploring the phthalates-induced neurotoxicity mechanisms of neurodegenerative diseases via network toxicology, single-cell transcriptomics and molecular dynamic simulation

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Authors

JLJie LiHYHongming YinZQZijie Qiu

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Overview

Exploring neurotoxicity mechanisms of phthalates in neurodegenerative diseases, suggesting new prevention strategies.

Key Points

  • This study investigates how phthalates may contribute to neurodegenerative diseases by impacting key cellular pathways.
  • Utilized network toxicology to identify phthalates affecting the blood-brain barrier.
  • Performed disease ontology analysis to link phthalates to Parkinson's disease, Lewy body disease, and Alzheimer's disease.
  • Conducted single-cell transcriptomic analysis to identify BCL2 as a key gene in phthalate-induced neurotoxicity.
  • Employed molecular dynamics simulations to assess interactions between phthalates and BCL2.
  • Executed cellular experiments to examine effects of DEHP and its metabolite on astrocyte transformation.
  • Identified ten phthalates with significant toxic effects on the blood-brain barrier.
  • Highlighted BCL2 as a critical hub gene in the neurotoxic pathways of phthalates.
  • Demonstrated that DEHP decreased BCL2 levels and altered astrocyte function in cell models.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69a91d9bd6127c7a504c091dhttps://doi.org/10.1016/j.ecoenv.2026.119954
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