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March 5, 2026Trials0 citationsOpen Access

Intraoperative breast cancer margin evaluation using fluorescence imaging with intravenous injection of indocyanine green (BREASTIFLU-1): study protocol for a randomized diagnostic accuracy trial of quantitative dose-timing assessment

CPC. Florin PopIVIsabelle VeysMMM. Moreau

Key Points

  • Evaluate the effectiveness of fluorescence imaging for assessing breast cancer margins during surgery.
  • Randomized diagnostic accuracy trial design
  • Intravenous injection of indocyanine green
  • Quantitative assessment of dose-timing
  • Comparison of margin evaluation techniques
  • Expected improvement in diagnostic accuracy for margin evaluation
  • Potential reduction in reoperation rates for breast cancer
  • Enhanced visualization of tumor margins during surgery

Abstract

This trial was registered on February 15, 2023 at Clinical Trials Information System EU2023-504024-26-00 and on September 10, 2023 at ClinicalTrials.gov NCT06227338.

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Cite This Study

Pop et al. (2026) studied this question.

synapsesocial.com/papers/69a91db5d6127c7a504c0c73https://doi.org/10.1186/s13063-026-09577-8
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