Синтез и биологическая активность производных изониазида и 2,4-динитрофенилгидразина, содержащих 1,3-диоксановый фрагмент

Key Points

• The aim is to synthesize derivatives of isoniazid and 2,4-dinitrophenylhydrazine containing a 1,3-dioxane fragment and evaluate their biological activities.
• Condensation of isoniazid or 2,4-dinitrophenyl hydrazine with substituted 5-acetyl-1,3-dioxanes.
• Selective synthesis of hydrazides and hydrazones from target compounds.
• Assessment of antiaggregatory and anticoagulatory activities of synthesized compounds.
• 1-(5-methyl-1,3-dioxane-5-yl)ethanone (2,4-dinitrophenyl)hydrazone exhibited the highest antiaggregatory activity.
• 1-(5-isopropyl-1,3-dioxane-5-yl)ethanone (2,4-dinitrophenyl)hydrazone showed the greatest anticoagulatory activity.