Analytical cross-sectional study examines serum magnesium's role in predicting insulin resistance in early CKD, suggesting its potential as a metabolic marker.
Key Points
The study aims to evaluate serum magnesium levels and their independent predictive value for insulin resistance in early chronic kidney disease.
Conducted as an analytical cross-sectional study at Jinnah Postgraduate Medical Centre in Karachi.
Involved 180 adults with CKD stages 1-3, enrolled through consecutive sampling.
Analyzed fasting blood samples for serum magnesium, glucose, insulin, and other biomarkers.
Assessed insulin resistance using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR).
Performed statistical analyses including one-way ANOVA and multivariate linear regression.
Serum magnesium levels significantly decline with advancing CKD stage (p<0.001).
HOMA-IR increases progressively across CKD stages (p<0.001).
A significant inverse correlation exists between serum magnesium and HOMA-IR (r = −0.52, p<0.001).
Serum magnesium is an independent predictor of insulin resistance after adjusting for confounding factors (β = −0.38, p<0.001).