Vitamin D inhibits the development of colorectal cancer cells by regulating the gut microbiota and immune microenvironment using JAKSTAT signaling pathway. | Synapse
Vitamin D inhibits the development of colorectal cancer cells by regulating the gut microbiota and immune microenvironment using JAKSTAT signaling pathway.
The aim is to explore how vitamin D influences colorectal cancer cell development through gut microbiota and immune responses.
Examined the effect of vitamin D on the JAK-STAT pathway activation.
Analyzed gut microbiota composition and butyrate metabolism.
Assessed macrophage polarization in response to vitamin D treatment.
Vitamin D reduced the activation of the JAK-STAT pathway.
Restoration of butyrate metabolism was observed.
Macrophage polarization was rebalanced, indicating improved immune response.
Resumen
Vitamin D inhibits excessive activation of the JAK-STAT pathway through VDR activation, ameliorates gut microbiota dysbiosis, restores butyrate metabolism, and rebalances macrophage polarization.