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March 6, 20260 citationsOpen Access

Toxoplasma gondii Infection and Proinflammatory Cytokine Level Assessment in Patients With Myocardial Infarction in Iraq: A Case-Control Study.

AJAl-Abbas Fadhil JasimAKAmal Khudair Khalaf

Key Points

  • To assess the relationship between Toxoplasma gondii infection and proinflammatory cytokine levels in myocardial infarction patients.
  • Case-control design comparing individuals with myocardial infarction and non-myocardial infarction groups.
  • Assessment of anti-T. gondii antibodies levels among participants.
  • Measurement of proinflammatory cytokines like IFN-γ and TGF-β.
  • Myocardial infarction patients exhibited significantly higher levels of anti-T. gondii antibodies compared to controls.
  • Increased concentrations of IFN-γ and TGF-β were observed in MI patients.
  • Findings suggest a potential role of T. gondii in the development of myocardial infarction through immune pathways.

Abstract

The present study revealed that individuals with MI exhibited significantly higher concentrations of anti-T. gondii antibodies compared to non-MI. The data further suggest that IFN-γ and TGF-β serve as critical biomarkers connected in the pathogenesis of MI. Our findings propose that T. gondii may contribute to the development of MI via immune-mediated inflammatory pathways. This observation indicates potential molecular similarities between the pathological elements of MI and the T. gondii pathogen. Moreover, the elevated expression of IFN-γ and TGF-β may offer a respected context for investigating the involvement of T. gondii in MI pathophysiology.

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Cite This Study

Jasim et al. (2026) studied this question.

synapsesocial.com/papers/69aa6ee2531e4c4a9ff590ddhttps://doi.org/10.1155/cjid/2553949
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