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March 6, 2026The European Journal of Health Economics0 citationsOpen Access

Cost-effectiveness analysis of influenza vaccination with high-dose vaccine versus standard-dose quadrivalent vaccine in older adults in Spain

JAJose-María Abellán-PerpiñánEMEsther Redondo MargüelloÁMÁngel Gil de Miguel

Key Points

  • The analysis aims to evaluate the cost-effectiveness of high-dose versus standard-dose influenza vaccines for older adults in Spain.
  • Conducted cost-effectiveness analysis comparing HD-QIV and SD-QIV
  • Evaluated influenza cases, medical visits, hospitalizations, deaths, and costs
  • Considered societal and NHS perspectives
  • HD-QIV reduces influenza cases compared to SD-QIV
  • Fewer GP and ED visits are associated with HD-QIV
  • Reduced hospitalizations and deaths with the high-dose vaccine
  • Lower overall costs from a societal and NHS viewpoint

Abstract

This analysis showed that vaccinating older adults in Spain with HD-QIV instead of SD-QIV would reduce cases of influenza, GP and ED visits, hospitalizations, deaths, and associated costs, and thus it should be the strategy of choice in a situation of budgetary constraints from either a societal or an NHS perspective.

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Cite This Study

Abellán-Perpiñán et al. (2026) studied this question.

synapsesocial.com/papers/69aa6f0d531e4c4a9ff5924fhttps://doi.org/10.1007/s10198-026-01894-8
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