Elevated prenatal maternal psychological distress was associated with lower motor scores (β=-0.64, p=0.003) and increased externalizing behaviors (β=0.21-0.50, p<0.01) in toddlers with congenital heart disease at 18 months.
Cohort (n=123)
No
Is prenatal maternal psychological distress associated with adverse 18-month neurodevelopmental outcomes in toddlers with congenital heart disease?
Elevated prenatal maternal psychological distress in pregnancies complicated by fetal CHD is significantly associated with impaired motor and social-emotional development in toddlers, as well as persistent postnatal parenting stress.
Estimación del efecto: β = -0.64 for motor score with prenatal maternal depression (EPDS) (p=0.003); β = 0.21 to 0.50 for increased externalizing behaviors with elevated prenatal anxiety, stress, and depression (p<0.01)
valor p: p=<0.0125 for significant associations after Bonferroni correction
The impact of maternal psychological distress on the long-term neurodevelopmental outcomes of toddlers with congenital heart disease (CHD) is unknown. This study examines the association between prenatal maternal distress and 18-month neurodevelopmental outcomes in toddlers with CHD. Increased prenatal maternal psychological distress is associated with impaired motor and social-emotional development in toddlers with CHD, as well as persistently elevated parenting stress. Associations between elevated prenatal maternal psychological distress and adverse motor and externalizing outcomes were stronger in toddlers with single-ventricle versus two-ventricle CHD. Identifying early risk factors for neurodevelopmental impairment in CHD toddlers is critical for developing early interventions that reduce maternal distress and improve long-term outcomes.
Wu et al. (Tue,) conducted a cohort in Pregnant women carrying fetuses with critical congenital heart disease requiring neonatal cardiac surgery (n=123). Elevated prenatal maternal psychological distress (stress, anxiety, depression) vs. Mothers without elevated prenatal psychological distress was evaluated on Toddler neurodevelopmental outcomes assessed by Bayley Scales of Infant and Toddler Development III and Infant-Toddler Social and Emotional Assessment at ~18 months (β = -0.64 for motor score with prenatal maternal depression (EPDS) (p=0.003); β = 0.21 to 0.50 for increased externalizing behaviors with elevated prenatal anxiety, stress, and depression (p<0.01), p=<0.0125 for significant associations after Bonferroni correction). Elevated prenatal maternal psychological distress was associated with lower motor scores (β=-0.64, p=0.003) and increased externalizing behaviors (β=0.21-0.50, p<0.01) in toddlers with congenital heart disease at 18 months.