PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 6, 2026Interventional Radiology0 citationsOpen Access

Hepatic Artery Embolization Reduces Tumor-infiltrating-CD8-positive Lymphocytes in an Orthotopic Rat Hepatocellular Carcinoma Model

HTHaruyuki TakakiRWReona WadaEUEisuke Ueshima

Key Points

  • This research aims to assess how hepatic artery embolization influences CD8-positive lymphocytes within tumor environments.
  • Evaluated the effects of hepatic artery embolization in a rat model of hepatocellular carcinoma.
  • Assessed changes in tumor-infiltrating CD8-positive lymphocytes using flow cytometry and immunohistochemistry.
  • Utilized an orthotopic rat model to closely mimic human tumor conditions.
  • Hepatic artery embolization significantly reduced the number of tumor-infiltrating CD8-positive lymphocytes.
  • The changes indicate a potential modulation of the tumor immune microenvironment following treatment.

Abstract

Purpose: Hepatic artery embolization is a locoregional treatment for hepatocellular carcinoma that may modulate the tumor immune microenvironment. However, its effects on tumor-infiltrating cluster of differentiation 8-positive lymphocytes remain unclear. This study evaluates changes in tumor-infiltrating cluster of differentiation 8-positive lymphocytes following hepatic artery embolization in an orthotopic rat hepatocellular carcinoma model using flow cytometry and immunohistochemistry.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Takaki et al. (2026) studied this question.

synapsesocial.com/papers/69aa6f3c531e4c4a9ff59564https://doi.org/10.22575/interventionalradiology.2025-0047
Ask AI
Helpful
Bookmark
Share
View Full Paper