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March 6, 2026Journal of the American Heart Association0 citationsOpen Access

Comparison of the Association of Area‐Based Deprivation Indices With Hypertension and Diabetes Control Outcomes

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SSSamuel SavitzJKJill M. KillianKYK. Yost

Key Result

Greater deprivation was associated with worse diabetes control (Yost RR 1.21; Area Deprivation Index RR 1.39), but not with hypertension control, in 67,386 hypertension and 30,435 diabetes patients.

Key Points

  • This research aims to evaluate and compare the performance of two area-based deprivation indices in relation to hypertension and diabetes control outcomes.
  • Cohort study conducted in a 19-county region of Southeast Minnesota
  • Identified adults with hypertension or diabetes
  • Operationalized deprivation indices as quintiles for state and national ranks
  • Utilized weighted kappa statistic to assess agreement between indices
  • Employed modified Poisson regression to assess associations with blood pressure or diabetes control
  • Identified 67,386 individuals with hypertension and 30,435 with diabetes
  • Moderate to substantial agreement between deprivation indices, higher for state rank (weighted kappa 0.68) than national rank (0.54)
  • No association found between deprivation indices and hypertension control
  • Greater deprivation linked to worse diabetes control for Yost Index (RR 1.21) and Area Deprivation Index (RR 1.39)
  • Similar model fit across indices but poorer for hypertension (AUC 0.53) than diabetes (AUC 0.63)

Structured PICO

Do area-based deprivation indices (Area Deprivation Index and Yost Index) predict hypertension and diabetes control in adults?

P
Population
67,386 adults with hypertension and 30,435 adults with diabetes in a 19-county region of Southeast Minnesota covered by the Rochester Epidemiology Project
I
Intervention
Area Deprivation Index (ADI)
C
Comparator
Yost Index
O
Outcome
Hypertension and diabetes control in 2022surrogate

Both the Area Deprivation Index and Yost Index are similarly associated with diabetes control, but not hypertension control, suggesting either is appropriate for diabetes-related health equity research.

Abstract

Background Area‐based deprivation indices have been linked to hypertension and diabetes outcomes, but limited information exists about their relative performance. We compared 2 area‐based deprivation measures (Area Deprivation Index and Yost Index) as risk factors for hypertension and diabetes control. Methods This cohort study identified adults with hypertension or diabetes in a 19‐county region of Southeast Minnesota covered by the Rochester Epidemiology Project. The deprivation indices were operationalized as quintiles for state and national ranks. We assessed agreement using the weighted kappa statistic. We used modified Poisson regression to evaluate associations of the deprivation indices with blood pressure or diabetes control in 2022. We compared relative model fit using the area under the receiver operating characteristic curve. Results We identified 67 386 individuals with hypertension and 30 435 with diabetes. There was moderate to substantial agreement between indices, but the agreement was higher for the state rank (weighted kappa 0.68 for both cohorts) than the national rank (0.54 for both). Although the indices were not associated with hypertension control, greater deprivation was associated with worse diabetes control for the Yost Index (relative risk RR, 1.21 95% CI, 1.07–1.38) and Area Deprivation Index (RR, 1.39 95% CI, 1.12–1.73) national ranks. The full‐model area under the receiver operating characteristic curve was similar across indices but differed across cohorts with worse fit for hypertension (0.53 for both) than diabetes (0.63 for both). Conclusions Two common area‐based deprivation indices had similar strength of association with diabetes control, suggesting that either index would be appropriate for researching and developing interventions for diabetes control.

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Cite This Study

Savitz et al. (2026) studied this question. Greater deprivation was associated with worse diabetes control (Yost RR 1.21; Area Deprivation Index RR 1.39), but not with hypertension control, in 67,386 hypertension and 30,435 diabetes patients.

synapsesocial.com/papers/69aa701a531e4c4a9ff5983ahttps://doi.org/10.1161/jaha.125.045324
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