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Synapse
March 6, 2026Diabetologia0 citationsOpen Access

The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis in a mouse model of diabetes by enhancing GLP-1 secretion and L cell differentiation

PPPhyllis PhuahMNMariana NortonYZYang Zou

Key Points

  • The research aims to understand how the microbial metabolite indole influences glucose regulation in diabetes.
  • Utilized a mouse model of diabetes for experimentation
  • Analyzed effects of indole on GLP-1 secretion
  • Investigated L cell differentiation through RNA sequencing
  • Indole significantly enhanced GLP-1 secretion
  • Promoted differentiation of L cells
  • Improved glucose homeostasis was observed in diabetic mice

Abstract

RNA sequencing data are available from the Gene Expression Omnibus under accession number GSE306720.

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Cite This Study

Phuah et al. (2026) studied this question.

synapsesocial.com/papers/69aa7027531e4c4a9ff599bfhttps://doi.org/10.1007/s00125-026-06688-4
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