The work presents the results of Monte Carlo modeling (PHITS) of irradiation of Fe3O4-SiO2-Au nanoparticles – promising agents for enhancing the effectiveness of radiation therapy with X-ray radiation. Within the model of a single nanoparticle in a water phantom, it was shown that, assuming a uniform distribution of gold nanoparticles over the surface of the adhesion layer, the particle density and their size do not have a significant impact on the efficiency of therapeutic X-ray beam conversion. The main factors determining the configuration of dose fields are the chemical composition of the nanoparticles and the energy of the primary photon beam.
Markin et al. (2025) studied this question.