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Synapse
March 6, 20260 citations

Tranexamic acid in spontaneous intracerebral hemorrhage: an updated systematic review and meta-analysis of randomized controlled trials.

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CQCuilin QueLFLuDa FengKCKegang Cao

Key Points

  • To determine the effects of tranexamic acid on outcomes in patients with spontaneous intracerebral hemorrhage.
  • Conducted systematic review of randomized controlled trials
  • Analyzed outcomes including all-cause mortality and functional results
  • Evaluated hematoma volume change with tranexamic acid use
  • Tranexamic acid did not affect all-cause mortality
  • No significant improvement in functional outcomes or neurological impairment
  • Reduced hematoma volume observed but no effect on hemorrhage expansion

Abstract

In summary, TXA does not affect all-cause mortality, functional outcomes, or neurological impairment, nor does it reduce HE, despite reducing hematoma volulume. TXA use for ICH requires careful clinical consideration.

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Cite This Study

Que et al. (2026) studied this question.

synapsesocial.com/papers/69aa7048531e4c4a9ff59f5ahttps://doi.org/10.1080/07853890.2026.2635208
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