PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 6, 20260 citations

Increased Cerebrospinal Fluid Lactate Levels in Schizophrenia and Major Depressive Disorder: NCNP Biobank Study in Japan.

View Full Paper
HHHideo HagiharaKHKotaro HattoriHKHiroshi Kunugi

Key Points

  • To evaluate cerebrospinal fluid lactate levels in individuals with schizophrenia and major depressive disorder.
  • Analyzed cerebrospinal fluid samples from individuals diagnosed with schizophrenia and major depressive disorder.
  • Compared lactate levels against established normal ranges.
  • Detected elevated cerebrospinal fluid lactate levels in individuals with schizophrenia.
  • Identified similar elevations in patients with major depressive disorder.
  • Concluded that elevated lactate levels may indicate altered brain energy metabolism rather than medication effects.

Abstract

This study confirmed elevated CSF lactate levels in Japanese individuals with schizophrenia and MDD, consistent with findings in other populations. The elevation of CSF lactate is unlikely to reflect medication effects and instead may represent an underlying pathophysiology associated with altered brain energy metabolism in the brain.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Hagihara et al. (2026) studied this question.

synapsesocial.com/papers/69aa70b8531e4c4a9ff5acd5https://doi.org/10.1002/npr2.70096
Ask AI
Helpful
Bookmark
Share
View Full Paper