Cross-sectional evaluation reveals WWI and lipocalin-2 predict cognitive impairment in type 2 diabetes, suggesting improved risk assessment methods.
Key Points
This research aims to assess the relationship between weight-adjusted waist index (WWI), lipocalin-2, and mild cognitive impairment (MCI) in patients with type 2 diabetes.
Conducted a cross-sectional study with 410 patients having type 2 diabetes.
Collected anthropometric data, metabolic indices, LCN2 levels, and neuropsychological test scores.
Divided participants into training (70%) and validation (30%) cohorts for model development.
Used LASSO regression for predictor selection and multivariable logistic models for analysis.
Evaluated model performance based on discrimination and calibration across cohorts.
Participants with MCI had significantly higher WWI and LCN2 levels compared to those with normal cognition.
After adjusting for other factors, WWI and LCN2 remained significant predictors of MCI with notable odds ratios.
The multivariable model showed satisfactory discrimination with AUC values of 0.745 and 0.774 in training and validation cohorts, respectively.
The combined model outperformed individual predictors, indicating the potential for better cognitive risk stratification.