Circ-Eif3c Carried by M2 Macrophage-Derived Exosomes Mitigates Asthma Progression via miR-15a-5p/GSS/SOCS6 Axis Inhibition.

Key Points

• The aim is to explore the role of circ-Eif3c-enriched exosomes in mitigating asthma progression.
• Analyzed the effects of M2 macrophage-derived exosomes on airway epithelial cells (AECs)
• Assessed the function of miR-15a-5p, GSS, and SOCS6 in airway remodeling
• Circ-Eif3c-enriched exosomes significantly improved AEC function
• Exosome treatment led to reduced airway remodeling

Abstract