Mechanosensitive Ion Channel PIEZO1 Suppresses BMP2-Induced Ossification of the Annulus Fibrosus Cells.

Key Points

• The research investigates how Piezo1 affects BMP2-induced ossification in annulus fibrosus cells under mechanical stress.
• Assessment of Piezo1 function in annulus fibrosus cells
• Analysis of BMP signaling pathway
• Evaluation of calcineurin's role in suppressing osteogenic changes
• Piezo1 inhibits BMP2-mediated ossification of annulus fibrosus cells
• Calcineurin mediates the suppression of BMP signaling
• Findings suggest potential therapeutic applications for intervertebral disc degeneration (IVDD)

Abstract