Dual-Activated Hydrocarboxylation of Acrylamides with Formate Salts via Radical–Radical Cross-Coupling

Key Points

• The study aims to develop a new method for hydrocarboxylation of acrylamides using radical-radical cross-coupling techniques.
• Developed a dual-activation strategy for alkene hydrocarboxylation
• Used an iron center to promote EDA complex formation
• Facilitated enol tautomerization to generate a stable allylic radical
• Assessed the process in generating succinamic and sulfamoyl propanoic acids
• Successfully demonstrated direct intermolecular coupling over cyclization
• Achieved a green route for synthesizing important compounds
• Established a controllable method for photochemical C-C bond formation

Abstract