Standardized guidelines restarting IV UFH 4-12 hours post-birth without bolus were generally followed, balancing bleeding and thrombotic risks in pregnant mechanical valve patients.
What are the haemorrhagic and thromboembolic outcomes and rates of protocol adherence when restarting IV UFH 4 to 12 hours after birth in pregnant patients with mechanical heart valves?
This retrospective case series evaluates clinical adherence to and outcomes of a standardized peripartum anticoagulation protocol for pregnant women with mechanical heart valves.
Tasa de eventos absoluta: 0% vs 0%
Aust N Z J Obstet Gynaecol . 2025;65:269-276. doi: 10.1111/ajo.13897. Women undergoing pregnancy with mechanical heart valves are a small population who present challenges in care with the need to carefully balance anticoagulation to prevent thrombosis while minimizing bleeding risk. While anticoagulation during pregnancy is essential, it presents significant challenges during the peripartum period, particularly immediately following delivery. At the Royal Brisbane and Women’s Hospital in Australia, standardized guidelines introduced in 2009 recommend restarting intravenous unfractionated heparin (IV UFH) 4 to 12 hours after birth without an initial bolus, with gradual dose increases and transition to warfarin. This retrospective study aimed to assess how closely clinical practice aligned with these recommendations and describe observed outcomes.
Aboud et al. (Sun,) reported a other. Standardized guidelines restarting IV UFH 4-12 hours post-birth without bolus were generally followed, balancing bleeding and thrombotic risks in pregnant mechanical valve patients.