Simultaneous profiling of chromatin accessibility and binding sites of DNA-associated proteins with scCPA-Tag

Key Points

• The aim is to simultaneously profile chromatin accessibility and DNA-associated protein binding in single cells.
• Utilized the BGI C4 platform for data capture
• Performed single-cell ATAC-seq on K562 cell line
• Conducted single-cell CUT&Tag on liver cancer samples
• Successfully captured chromatin accessibility and binding data in single cells
• Identified specific protein interactions in K562 and liver cancer cells

Abstract