Component Clinical and Cost Outcomes Complementing Value of Information: Case Study of a Tuberculosis Diagnostics Clinical Trial

Key Points

• This research addresses the importance of evaluating both clinical and cost outcomes in the value of information (VOI) framework for tuberculosis diagnostics.
• Conducted a clinical trial focusing on tuberculosis diagnostics.
• Analyzed both aggregated net monetary benefit (NMB) and disaggregated clinical outcomes.
• Evaluated cost savings alongside clinical effectiveness to inform decision-making.
• Identified instances where positive NMB might hide unfavorable clinical outcomes.
• Highlighted that aggregated VOI may not fully capture the impacts of diagnostics.
• Suggested incorporating detailed outcomes in VOI studies for better prioritization.

Abstract