Fluoroquinolones and the risk of panic attacks: a systematic review and disproportionality analysis using individual case safety reports from the FDA Adverse Event Reporting System (FAERS) database

Key Points

• To investigate the association between fluoroquinolones and panic attacks using adverse event reports.
• Conducted a systematic review of existing literature
• Performed a disproportionality analysis using the FAERS database
• Analyzed individual case safety reports of adverse events
• Found an association suggesting increased panic attack risk with fluoroquinolone use
• Emphasized the need for validation through further pharmacoepidemiological studies
• Highlighted limitations in determining causal relationships due to reliance on spontaneous reports

Abstract