Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization

Key Points

• This research examines how genetically predicted interleukin-6 and tumor necrosis factor signaling pathways associate with mortality in colorectal cancer.
• Used two-sample Mendelian randomization to analyze genetic data
• Evaluated associations between IL-6 and TNF-related pathways and colorectal cancer outcomes
• Investigated mortality rates among colorectal cancer patients
• IL-6 signaling is associated with colorectal cancer progression, albeit limited
• TNF-related pathways show less relevance for prognosis in colorectal cancer cases

Abstract