Early Multimodal Assessment for Prediction of Cerebral Palsy in Neonatal Hypoxic-Ischemic Encephalopathy

Key Points

• The aim is to evaluate early multimodal assessments for predicting cerebral palsy (CP) in neonates with hypoxic-ischemic encephalopathy (HIE).
• Utilized aEEG as a biomarker for CP prediction after HIE.
• Combined aEEG with MRI for enhanced diagnostic precision.
• Assessed additional screening value of HNNE and GMA in early diagnosis.
• Recommended standardized multimodal protocols for clinical integration.
• aEEG proved to be a robust and independent biomarker for CP prediction.
• Combining aEEG and MRI significantly improved diagnostic accuracy.
• HNNE and GMA were found inadequate as standalone assessments.
• Integration of multimodal assessments is essential for better prognosis.

Abstract