PAH-former: Transfer learning for efficient discovery of pulmonary arterial hypertension-associated genes

Key Points

• The aim is to develop a platform for efficient discovery of genes linked to pulmonary arterial hypertension.
• Developed a transfer learning model called PAH-former.
• Utilized limited data for identification of candidate genes.
• Applied the model for mechanistic insights into disease pathways.
• Enabled the identification of new candidate genes for PAH.
• Showed promise for accelerating therapeutic development.
• Provided insights into cell-specific mechanisms of the disease.

Abstract