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IgG4 on the dance floor: Partners swapped by Fab-arm exchange | Synapse

March 8, 2026

IgG4 on the dance floor: Partners swapped by Fab-arm exchange

Key Points

This research aims to explore the processes and implications of Fab-arm exchange in IgG4 antibodies.
Conducted proteomic analysis of circulating IgG4 antibodies.
Identified occurrence and extent of Fab-arm exchange.
Characterized the bispecific antibody repertoire generated.
Nearly all circulating human IgG4 undergoes Fab-arm exchange.
A vast bispecific antibody repertoire is created through this process.

Abstract

Proteomic analysis shows that nearly all circulating human IgG4 undergoes Fab-arm exchange, creating a vast bispecific antibody repertoire.

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Authors

A

Ailis Grieshaber

K

Kevin C. O’Connor

Journals

Science Immunology

Actions

Institutions

Yale University

References and Citations

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Cite this study

Grieshaber et al. (Fri,) studied this question.

www.synapsesocial.com/papers/69ada962bc08abd80d5bca55 — DOI: https://doi.org/10.1126/sciimmunol.aeg6827