Obstructive sleep apnea severity, Alzheimer's disease plasma markers, and CSF brain amyloidosis and tau pathology.

Key Points

• This research investigates the relationship between obstructive sleep apnea severity and Alzheimer’s disease plasma markers and CSF pathology.
• Analyzed plasma Aβ levels and CSF indicators of amyloidosis and tau pathology.
• Evaluated the relationship between obstructive sleep apnea severity and biomarkers.
• Combined measures of plasma and OSA to enhance detection of Alzheimer’s disease associations.
• OSA severity corresponds with elevated plasma Aβ levels.
• Combined plasma and CSF measures reveal associations with tau and neurofilament light chain (NfL).
• Findings suggest non-invasive methods for identifying Alzheimer’s pathology.

Abstract