The simulated deployment of a novel Asymmetric Artificial Interventional Valve in a bicuspid aortic valve resulted in a maximum stress of 0.590 MPa, 8.2% lower than that of a standard THV (0.643 MPa).
Does an Asymmetric Artificial Interventional Valve (AAIV) reduce mechanical stress compared to a standard transcatheter heart valve in simulated bicuspid aortic valve deployment?
A novel asymmetric transcatheter valve design reduces mechanical stress by 8.2% compared to standard valves in simulated bicuspid aortic valve deployments, potentially improving durability.
Effect estimate: 8.2% lower
Absolute Event Rate: 0.59% vs 0.643%
When a Transcatheter heart valve (THV) is implanted in a bicuspid aortic valve (BAV), the interventional valve may experience elliptical deformation, thereby reducing its durability. In this study, a novel Asymmetric Artificial Interventional Valve (AAIV) was designed. The deployment of the AAIV in the BAV was simulated and compared to that of a THV. The synergistic effects of the AAIV (0.1, 0.2, and 0.3) eccentricity and annulus eccentricity (0.1, 0.2, and 0.3) on the deployment of the interventional valve were studied. Besides, the influence of native leaflet calcification on the deployment of the AAIV was also studied. The results demonstrated the maximum stress of the AAIV (0.590 MPa) is 8.2% lower than that of the THV (0.643 MPa). When the AAIV eccentricity is equal to the annulus eccentricity, the stress of the prosthetic valve is the highest, representing the most unfavorable condition for the long-term durability of the prosthetic valve. Calcification of the native leaflet can increase the stress of the prosthetic valve. In addition, with the increase of annulus eccentricity, the stress of the prosthetic valve tends to increase. This study might provide insights for the design of personalized high-performance interventional valves and their rational selection in clinical practice.
Shen et al. (Thu,) conducted a other in Bicuspid aortic valve. Asymmetric Artificial Interventional Valve (AAIV) vs. Transcatheter heart valve (THV) was evaluated on Maximum stress of the prosthetic valve (8.2% lower). The simulated deployment of a novel Asymmetric Artificial Interventional Valve in a bicuspid aortic valve resulted in a maximum stress of 0.590 MPa, 8.2% lower than that of a standard THV (0.643 MPa).