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March 10, 2026Head & Neck0 citations

Inter‐Rater Agreement in the Interpretation of Extranodal Extension of Metastatic Squamous Cell Carcinoma—A Multi‐Institutional Study

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LSLeba M. SarkisSSStephen M. SmithSSSusie Su

Key Points

  • The aim is to assess the consistency in diagnosing extranodal extension in metastatic squamous cell carcinoma among pathologists.
  • Multi-institutional assessment across high volume tertiary Head and Neck centers
  • Evaluation of histopathological diagnoses of extranodal extension
  • Comparison of interpretations among different pathologists
  • Observed only slight to fair consistency in diagnoses of extranodal extension
  • Indicates variability in interpretation among pathologists across institutions

Abstract

These findings of only slight to fair consistency in the histopathological diagnosis and characterization of ENE across multiple high volume tertiary Head and Neck centers suggest the imperative need for a consensus guideline among pathologists in both processing of lymph nodes and interpretation.

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Cite This Study

Sarkis et al. (2026) studied this question.

synapsesocial.com/papers/69af94e870916d39fea4bf29https://doi.org/10.1002/hed.70199
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