Background The Q‐switched Nd:YAG laser (1064‐nm) has been reported to be the best choice for keratosis pilaris (KP) with a high frequency of treatment. Glycolic acid (GA) is known to correct abnormal keratinization and accelerate melanin metabolism. However, the combined effect of Q‐switched Nd:YAG laser (1064‐nm) and GA on KP has not been studied. Objective To evaluate the efficacy and safety of combining Q‐switched Nd:YAG laser (1064‐nm) with 30% GA in the treatment of KP. Method This prospective, rater‐blinded split‐body comparative study was conducted on patients with bilateral KP on their upper arm. Each participant’s arms were randomly assigned to either the combination group (treated with 30% GA followed by Q‐switched Nd:YAG laser) or the control group (treated with Q‐switched Nd:YAG laser alone). Treatments were administered in four sessions, 3 weeks apart. The primary endpoint was the difference in average physicians’ assessment scores between groups. The secondary endpoints were the patients’ self‐assessment scores, dermoscopic and ultrasonographic improvements, and adverse effects. Clinical, dermoscopic, and ultrasonographic assessments were conducted at baseline and 4 weeks after the final treatment. Result A total of 22 patients completed the study. Physicians’ assessment indicated significant improvements in both roughness and redness scores from baseline to final follow‐up in both groups (all p 0.05). However, the combination group led to significantly greater improvement in follicular plugs and, on high‐frequency ultrasound, in the number of epidermal bulges (both p < 0.05). No severe adverse effects were reported in either group. Conclusion The combined therapy of Q‐switched Nd:YAG laser (1064‐nm) and 30% GA has the enhanced effect in treating KP, offering significant improvements in skin texture with a favorable safety profile. Trial Registration: Chinese Clinical Trial Registry: ChiCTR2100054489
Li et al. (Thu,) studied this question.