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March 10, 2026Scientific Reports0 citationsOpen Access

Synthesis and biological evaluation of ibuprofen/o-vanillin Schiff base complexes with anti-inflammatory, anti-proliferative and anti-SARS-COV-19 activities

LALaila H. Abdel‐RahmanDEDoaa Abou El-ezzAAAbdel-Mawgoud Abdel-Mawgoud

Key Points

  • The aim is to synthesize and evaluate the anti-inflammatory and anti-COVID-19 activities of ibuprofen metal complexes.
  • Synthesis of four metal-complexes using copper(II), nickel(II), zinc(II), and vanadium(IV) salts with ibuprofen Schiff base ligand.
  • Characterization of the complexes to confirm their formation.
  • Assessment of anti-inflammatory and anti-COVID-19 activities through in-vitro tests.
  • The copper complex demonstrated the highest antibacterial and cytotoxic efficiency.
  • Strong binding interactions with DNA were observed specifically in the copper complex.
  • Ranking of anti-inflammatory and anti-COVID-19 potencies: CuL > NiL > ZnL > VOL > HL.

Abstract

This study presents the synthesis and comprehensive characterization of four novel metal-complexes formed from the reaction of copper(II), nickel(II), zinc(II), and vanadium(IV) salts with the bidentate ibuprofen Schiff base ligand (HL) in 1:1 metal-to-ligand ratio. The copper complex shows the highest antibacterial and cytotoxicity efficiency, in addition to a strong binding interactions with DNA. The in-vitro anti-inflammatory and anti-COVID-19 potencies of HL and its complexes were assessed, ranking them as: CuL > NiL > ZnL > VOL > HL.

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Cite This Study

Abdel‐Rahman et al. (2026) studied this question.

synapsesocial.com/papers/69af954870916d39fea4ca73https://doi.org/10.1038/s41598-026-38270-8
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