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Female-specific Cx3cr1-driven regulation of ALS and Alzheimer’s risk genes in tauopathy | Synapse

March 10, 2026Molecular Neurodegeneration Advances0 citationsOpen Access

Female-specific Cx3cr1-driven regulation of ALS and Alzheimer’s risk genes in tauopathy

ASAri Sudwarts GTGopal Thinakaran

Puntos clave

To investigate how Cx3cr1 haploinsufficiency affects ALS and Alzheimer’s risk genes in a tauopathy model.
Utilized P301S (PS19) transgenic model of tau pathology.
Induced haploinsufficiency of Cx3cr1.
Analyzed transcriptional changes in genetic risk factors for ALS and Alzheimer’s.
Notable transcriptional changes observed in ALS and Alzheimer’s risk genes.
Several risk genes showed co-expression, indicating possible gene-gene interactions.
Findings suggest that Cx3cr1 has a sex-specific role in regulating these risk genes.

Resumen

By introducing haploinsufficiency of Cx3cr1 in the P301S (PS19) transgenic model of tau pathology, we report remarkable transcriptional changes, including crucial amyotrophic lateral sclerosis and Alzheimer’s disease risk genes, several of which showed co-expression, suggesting gene–gene interactions among these genetic risk factors.

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Cite This Study

Sudwarts et al. (Sun,) studied this question.

synapsesocial.com/papers/69af954870916d39fea4cb12 https://doi.org/https://doi.org/10.1186/s44477-026-00022-3

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