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March 10, 2026Diabetologia0 citationsOpen Access

Mitochondrial cristae density is increased following high-intensity interval training in men with type 2 diabetes

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MAMartin E. de AlmeidaNØNiels ØrtenbladAPAugustenburger Platz

Key Points

  • The aim is to investigate if high-intensity interval training affects mitochondrial cristae density in individuals with type 2 diabetes.
  • Compared mitochondrial cristae density in men with type 2 diabetes and individuals with obesity and lean individuals.
  • Examined cristae remodeling capacity following high-intensity interval training.
  • Analyzed skeletal muscle samples pre-and post-intervention.
  • No initial difference in cristae density between type 2 diabetes and control groups.
  • High-intensity interval training significantly increased mitochondrial cristae density in men with type 2 diabetes.
  • Mitochondrial architecture showed plasticity despite the presence of type 2 diabetes.

Abstract

Skeletal muscle mitochondrial cristae density is not different between individuals with type 2 diabetes and glucose-tolerant individuals with obesity and lean individuals, and the capacity for cristae remodelling in response to exercise is not affected by type 2 diabetes. These findings highlight the plasticity of mitochondrial architecture and support HIIT as a potent stimulus for improving muscle oxidative and metabolic health in type 2 diabetes.

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Cite This Study

Almeida et al. (2026) studied this question.

synapsesocial.com/papers/69af955970916d39fea4cc47https://doi.org/10.1007/s00125-026-06694-6
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