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March 10, 2026International Endodontic Journal0 citations

Subgingival Microbial Signatures Associated With Apical Periodontitis Identified by Next Generation Sequencing and Predictive Modelling

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MBMarcelo BritosEPElizabeth PellegriniPHPatricia Hernández‐Ríos

Key Points

  • The research aims to identify distinct microbial signatures associated with apical periodontitis and evaluate their diagnostic accuracy.
  • Utilized next generation sequencing to analyze subgingival samples
  • Compared microbial profiles of apical periodontitis individuals to healthy controls
  • Employed predictive modelling to assess signature accuracy.
  • Identified distinct microbial profiles in individuals with apical periodontitis
  • Demonstrated high diagnostic accuracy for specific bacterial signatures
  • Observed dysbiosis in subgingival microbiota of affected individuals.

Abstract

Subgingival profiles from AP individuals are distinct from those in healthy controls, showing AP-associated dysbiosis. Specific subgingival bacterial signatures achieved high diagnostic accuracy, supporting the potential broader impact of AP on the subgingival microbiota.

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Cite This Study

Britos et al. (2026) studied this question.

synapsesocial.com/papers/69af957570916d39fea4d17bhttps://doi.org/10.1111/iej.70131
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