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March 10, 2026ChemistrySelect0 citations

Therapeutic Potential of BODIPY‐Based Lignin Nanosensitizers as Sustainable ROS Generators

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SKSeema KirarAPAnil Kumar PujariSDSouram De

Key Points

  • The aim is to explore lignin-based BODIPY nanosensitizers for antimicrobial applications via singlet oxygen generation.
  • Developed electron-withdrawing haloaryl/halonitroaryl substituted BODIPY photosensitizers.
  • Isolated lignin from areca nut waste using autoclaving.
  • Characterized the photophysical properties of BODIPY-based nanosensitizers.
  • Evaluated antimicrobial effectiveness through in vitro testing.
  • BODIPY-based nanosensitizers showed superior photophysical properties compared to native counterparts.
  • Demonstrated efficient singlet oxygen generation.
  • Effectively inhibited pathogens, showcasing potential as an antimicrobial platform.

Abstract

ABSTRACT The sustained demand for advanced antimicrobial agents highlights lignin as a renewable and environmentally friendly biopolymer. Sustainable biopolymer lignin (agri‐waste‐based) derived nanostructures were developed to achieve water solubility of photosensitizers. For that, we have prepared a series of electron‐withdrawing haloaryl/halonitroaryl substituted BODIPY as photosensitizer probes. Subsequently, lignin was isolated from areca nut waste (leaf sheath) using the autoclave method. BODIPY‐based nanosensitizers have demonstrated significantly better in vitro photophysical properties than their native counterparts. The developed photonanosensitizers were successfully used in pathogen inhibition due to their efficient singlet oxygen generation. The persistent demand for effective antimicrobial materials underscores the potential of lignin, a renewable biopolymer, when functionalized with BODIPY dyes, to serve as an efficient antimicrobial platform.

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Cite This Study

Kirar et al. (2026) studied this question.

synapsesocial.com/papers/69af959570916d39fea4d4d9https://doi.org/10.1002/slct.202506468
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