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March 10, 2026CNS Neuroscience & Therapeutics0 citationsOpen Access

SMPD1 as a Potential Prognostic Biomarker in Glioma Is Associated With an Immunosuppressive Microenvironment

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YXYanan XuXLXia LiuBXBoya Xu

Key Points

  • This research aims to evaluate SMPD1 as a prognostic biomarker and its role in creating an immunosuppressive environment in gliomas.
  • Assessment of SMPD1 expression levels in glioma samples
  • Analysis of the relationship between SMPD1 and tumor microenvironment characteristics
  • Evaluation of the implications for glioma immunotherapy
  • SMPD1 is significantly upregulated in glioma tissues
  • Higher SMPD1 levels correlate with an immunosuppressive microenvironment
  • SMPD1's expression may promote tumor progression and affect treatment responses

Abstract

SMPD1 is a potential biomarker and therapeutic target in gliomas. Its upregulation may contribute to the formation of an immunosuppressive microenvironment and promote tumor progression, highlighting its potential relevance in glioma immunotherapy.

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69af959570916d39fea4d5b4https://doi.org/10.1002/cns.70813
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