Proteomic characterization of cochlea vascular injury and PVM/Ms-associated repair using iTRAQ and PRM approaches

Puntos clave

• To characterize proteomic changes related to cochlear vascular injury and the associated repair processes involving PVM/Ms.
• Utilized iTRAQ and PRM techniques for proteomic analysis
• Focused on the disruption of the PVM/Ms-VEGF/PEDF-junctional protein axis
• Investigated time-dependent responses to NE
• Identified disruption in PVM/Ms-VEGF/PEDF junctional protein axis
• Demonstrated instability in the blood-labyrinth barrier (BLB)
• Outlined potential repair pathways linked to PVM/Ms activity