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March 12, 2026Pediatric Surgery International0 citationsOpen Access

Mesenchymal stromal cell therapy restores intestinal integrity and attentuates inflammation in a preterm piglet model of necrotizing enterocolitis

JLJasmine LeeSJSharon JosephKMKrishna Manohar

Key Points

  • The study aims to evaluate the therapeutic effects of mesenchymal stromal cells on intestinal health in a preterm piglet model of necrotizing enterocolitis.
  • Utilized a preterm piglet model of necrotizing enterocolitis.
  • Administered mesenchymal stromal cell therapy to assess its effects.
  • Monitored changes in intestinal integrity and inflammation levels.
  • Demonstrated improved intestinal integrity in treated piglets.
  • Reduced inflammation observed in the intestinal tissues.
  • Support for the potential application of MSC therapy in clinical settings.

Abstract

This is the first study to demonstrate therapeutic benefit of MSCs in a preterm piglet NEC model, supporting their potential use in translational NEC therapies.

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Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69b2575e96eeacc4fcec5f9chttps://doi.org/10.1007/s00383-026-06324-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  4. 4Understanding the Susceptibility of the Premature Infant to Necrotizing Enterocolitis (NEC)2008 · 252 citations
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