As life evolved from simple vesicles to complex eukaryotic cells, the strategy of "starting over" was replaced by a rigid hierarchy of genetic information. This article analyzes this transition through the lens of Prigogine’s "arrow of time." We argue that modern complexity introduces a thermodynamic trap: irreversibility. In a highly specialized system, a perturbation does not lead to a safe dissolution but to a bifurcation point. We define cancer not as mere chaos, but as a robust, pathological "biological attractor." Once the system crosses this threshold, the high informational cost makes a return to the healthy state thermodynamically improbable, marking the end of the "Second Chance" era.
Peter Mikuláš (Mon,) studied this question.