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March 12, 2026International Endodontic Journal0 citations

Sensory Nerves Regulate Odontoblast Differentiation via the SPP1/ITGA4 Axis During Tooth Root Development

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HZHuanyan ZuoJHJiahao HanJWJiawei Wu

Key Points

  • To explore the mechanism by which sensory nerves influence odontoblast differentiation during tooth root development.
  • Investigated the crosstalk between sensory nerves and progenitor cells.
  • Examined the role of the SPP1/ITGA4 axis in regulation.
  • Utilized models of tooth root development to assess differentiation effects.
  • Sensory nerves significantly regulate odontoblast differentiation.
  • The SPP1/ITGA4 axis is a crucial pathway in this process.
  • Findings imply potential applications in stem cell therapies for tooth regeneration.

Abstract

Collectively, our findings elucidate a novel mechanism whereby sensory nerves orchestrate tooth root development by regulating progenitor cell fate through the SPP1/ITGA4 axis. This neuro-mesenchymal crosstalk provides insights for stem cell therapies and tooth root regeneration.

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Cite This Study

Zuo et al. (2026) studied this question.

synapsesocial.com/papers/69b257cd96eeacc4fcec6bc4https://doi.org/10.1111/iej.70129
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