Background: Primary brain sarcomas are exceedingly rare mesenchymal tumors of the central nervous system, representing a very small proportion of intracranial malignancies.Our aim in this study was to determine the prognosis of patients with brain sarcoma.Methods: This retrospective cohort study was conducted using the Surveillance, Epidemiology, and End Results (SEER) database to identify patients diagnosed with primary brain sarcoma between 2000 and 2022.Demographic, clinicopathological, and treatment information were collected.Survival outcomes were analyzed using the Kaplan-Meier method, and independent prognostic factors were determined with multivariate Cox proportional hazards models.Results: Analysis was performed using data from 266 patients who met the study criteria.The majority of patients were under 60 years of age (71.1%).The most common brain regions affected were the frontal (29.6%), parietal (15.7%), and temporal (15.3%) lobes.The most common sarcoma types were solitary fibrous tumor (32.7%), sarcoma, NOS (20.3%), spindle cell sarcoma (9%), and rhabdomyosarcoma (7.1%).Patients were more often diagnosed in the early stage (localized-74.4% and locally advanced-17.9%).Cancer-related surgery was performed in 87.9% of patients, 58.2% received radiotherapy, and 25.9% received chemotherapy.In patients with metastatic disease, the most common sites of metastasis were the lung (2.6%) and liver (1.1%).The 1-, 3-, and 5-year survival rates were 75%, 63.4%, and 57.7%, respectively.The median survival time was 106 months (95% CI,).Factors affecting survival were evaluated using multivariate analysis and were identified as age (p<0.001),gender (p=0.007),sarcoma type (p<0.001),tumor site (p=0.183),surgery (p=0.854),radiotherapy (p<0.001),chemotherapy (p=0.380), and stage at diagnosis (p=0.004). Conclusions:This study demonstrates the clinicopathological features and prognoses at diagnosis in patients with brain sarcoma, a rare condition.Initial stage and sarcoma type were identified as the most critical parameters affecting disease prognosis.Although surgery is the primary treatment for sarcoma, we detected that radiotherapy affects prognosis as an independent variable.
Yerlikaya et al. (Sun,) studied this question.