Objective: This study aimed to investigate the association between the triglyceride-glucose (TyG) index and hyperuricemia (HUA) in hospitalized patients with depression and to explore subgroup heterogeneity, thus providing evidence for early prevention and management of HUA in this population. Methods: A retrospective cross-sectional study was conducted on 3196 hospitalized patients with depression (aged ≥ 18 years) admitted to the Affiliated Mental Hospital of Anhui Medical University between May 2022 and June 2024. HUA was defined as serum uric acid (SUA) > 420 μmol/L in men and > 360 μmol/L in women. After assessing multicollinearity using variance inflation factors (VIF), we performed hierarchical multivariable logistic regression to examine the association between the TyG index and HUA. Restricted cubic spline (RCS) analysis and quartile grouping were used to explore the dose-response relationship. Subgroup analyses were conducted to investigate potential heterogeneity. Results: The overall prevalence of HUA was 11.5% (16.0% in men and 9.5% in women). After adjusting for potential confounders, the TyG index was significantly associated with HUA risk (OR = 1.76, 95% CI: 1.37– 2.25, p < 0.001). RCS analysis revealed a positive dose-response relationship between the TyG index and HUA risk, with an accelerated increase observed when the TyG index exceeded 9. A TyG index ≥ 9 was identified as a potential risk threshold. Conclusion: The TyG index is an independent risk factor for HUA in hospitalized patients with depression. Incorporating the TyG index into metabolic risk assessment may facilitate early identification and intervention of HUA in this population. Keywords: depression, TyG index, hyperuricemia, cross-sectional study
Zhang et al. (Sun,) studied this question.